Hi I'm Dan.
This is my first post, so I hope I don't break any rules. I did a search before I posted and didn't find anything about Rocksmith. I have to tell my lefty brethren about this sweet new program.
As a 45 y.o. newbie lefty guitar player, I have met the resistance common to the lefty player from teachers, transcriptions, chord charts, lack of gear, etc. It has continuously made the difficult task of learning guitar harder.
So, I was really pleased when I bought the Rocksmith game for PS3. It plugs into a real electric guitar, has a full featured left handed mode, and IT MAKES PRACTICE FUN! I played my guitar continuously last night until my fingers were too sore to continue, and I want to do it again as soon as possible!
There are a few things in Rocksmith, like video cutscenes, where the guitar is not left handed, but as far as the chords, notes, mini practice games, and songs go everything gets flipped and reversed to be set up perfectly for lefties, just bring your skill (or lack of ,in my case). In one minigame there is a baseball player who even switches to lefty when the mode is changed to lefty.
For any left handed guitar players with game consoles, this is a really, really, great piece of software, a must buy really if you're frustrated like I was. I hope you all buy it and try out the lefty mode with your ax of choice. Anything with 1/4" plug is supposed to work, all the guitars I've tried work fine.
With the limited resources available to lefties this program really shines. If I didn't have a console, I'd buy a used one just for this software. I'd buy a TV too if I didn't have one. It's that good. It really, really is nice for guitar playing lefties.
Hooking up the sound correctly takes a small effort, but I bet you can figure it out.
I know you don't know me, but I am really not one for hyperbole. For a lefty guitar player, this program is something to get excited about!
Six lefty stars out of five - Truly spectacular